Remo Guerrini Selected Research

(Nphe(1),Arg(14),Lys(15))N-OFQ NH(2)

1/2017	Effects of [Nphe1, Arg14, Lys15] N/OFQ-NH2 (UFP-101), a potent NOP receptor antagonist, on molecular, cellular and behavioural alterations associated with chronic mild stress.
1/2013	The nociceptin/orphanin FQ receptor antagonist UFP-101 reduces microvascular inflammation to lipopolysaccharide in vivo.
12/2008	The nociceptin/orphanin FQ-NOP receptor antagonist effects on an animal model of sepsis.
11/2007	Proinflammatory and vasodilator effects of nociceptin/orphanin FQ in the rat mesenteric microcirculation are mediated by histamine.
5/2005	[Nphe1,Arg14,Lys15]N/OFQ-NH2 is a competitive antagonist of NOP receptors in the periaqueductal gray.

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Remo Guerrini Research Topics

Disease

9	Neoplasms (Cancer) 01/2023 - 08/2011
8	Pain (Aches) 01/2021 - 02/2002
7	Ovarian Neoplasms (Ovarian Cancer) 12/2022 - 08/2011
4	Sepsis (Septicemia) 01/2023 - 12/2008
4	Hypotension (Low Blood Pressure) 11/2016 - 04/2003
3	Inflammation (Inflammations) 01/2023 - 11/2007
3	Respiratory Hypersensitivity 04/2016 - 02/2010
3	Parkinson Disease (Parkinson's Disease) 06/2014 - 10/2005
3	Tics (Tic) 07/2004 - 01/2002
2	Breast Neoplasms (Breast Cancer) 12/2022 - 11/2015
2	Substance-Related Disorders (Drug Abuse) 01/2021 - 03/2017
2	Cough 01/2021 - 03/2005
2	Overactive Urinary Bladder (Overactive Bladder) 01/2019 - 01/2019
2	Alzheimer Disease (Alzheimer's Disease) 01/2018 - 11/2002
2	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2013 - 08/2012
2	Prion Diseases (Transmissible Spongiform Encephalopathies) 08/2012 - 09/2005
2	Alcoholism (Alcohol Abuse) 11/2006 - 01/2002
2	Parkinsonian Disorders (Parkinsonism) 10/2005 - 12/2004
2	Bradycardia 08/2005 - 04/2003
1	Psoriatic Arthritis 01/2023
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2023
1	Erectile Dysfunction 01/2022
1	Dementia (Dementias) 11/2021
1	Cognitive Dysfunction 11/2021
1	Melanoma (Melanoma, Malignant) 05/2021
1	Infections 05/2021
1	Thalassemia 10/2020
1	Hemoglobinopathies 10/2020
1	Sickle Cell Anemia (Hemoglobin S Disease) 10/2020
1	Schizophrenia (Dementia Praecox) 01/2019
1	Isolated Systolic Hypertension 01/2019
1	Bipolar Disorder (Manic Depressive Psychosis) 01/2019
1	Personality Disorders (Personality Disorder) 01/2019
1	Mental Disorders (Mental Disorder) 03/2017
1	Anhedonia 01/2017
1	Chronic Pain 01/2017

Drug/Important Bio-Agent (IBA)

18	NociceptinIBA 01/2023 - 02/2002
13	Peptides (Polypeptides)IBA 01/2022 - 11/2002
10	Proteins (Proteins, Gene)FDA Link 12/2022 - 11/2002
7	Thymidylate SynthaseIBA 12/2022 - 08/2011
7	NeuropeptidesIBA 01/2021 - 10/2005
7	LigandsIBA 03/2017 - 01/2002
5	(Nphe(1),Arg(14),Lys(15))N-OFQ NH(2)IBA 01/2017 - 05/2005
4	Nociceptin ReceptorIBA 01/2023 - 11/2006
4	EnzymesIBA 12/2022 - 08/2011
4	Anti-Anxiety Agents (Anxiolytics)IBA 03/2017 - 12/2008
3	LipopolysaccharidesIBA 01/2023 - 01/2013
3	Opioid Receptors (Opioid Receptor)IBA 01/2017 - 11/2015
3	Oxidopamine (6 Hydroxydopamine)IBA 06/2014 - 10/2005
3	Opioid Analgesics (Opioids)IBA 01/2013 - 02/2002
3	Capsaicin (Zostrix)FDA Link 02/2010 - 03/2005
2	Peptidoglycan (Murein)IBA 01/2023 - 01/2022
2	Fluorouracil (Carac)FDA LinkGeneric 12/2022 - 09/2019
2	Growth InhibitorsIBA 09/2019 - 12/2014
2	PlatinumIBA 09/2019 - 08/2011
2	Amyloid (Amyloid Fibrils)IBA 01/2018 - 11/2002
2	Analgesics (Analgesic Drugs)IBA 03/2017 - 08/2016
2	6'- fluoro- 4',9'- dihydro- N,N- dimethyl- 4- phenylspiro(cyclohexane- 1,1'(3'H)- pyrano(3,4- b)indol)- 4- amineIBA 01/2017 - 08/2016
2	Morphine (MS Contin)FDA LinkGeneric 11/2015 - 01/2010
2	Opioid Peptides (Opioid Peptide)IBA 11/2015 - 01/2002
2	Nphe(1)- (pF)Phe(4)- Aib(7)- Arg(14)- Lys(15)- nociceptin-amideIBA 11/2015 - 01/2010
2	Cisplatin (Platino)FDA LinkGeneric 11/2014 - 08/2011
2	fluorescein isothiocyanate bovine serum albuminIBA 01/2013 - 11/2007
2	Prion ProteinsIBA 08/2012 - 09/2005
2	delta Opioid Receptors (delta Opioid Receptor)IBA 07/2004 - 12/2002
2	2',6'- dimethyltyrosyl- 1,2,3,4- tetrahydroisoquinoline- 3- carboxylic acidIBA 07/2004 - 12/2002
2	AcidsIBA 12/2002 - 01/2002
1	Imiquimod (Aldara)FDA LinkGeneric 01/2023
1	SulfonamidesIBA 01/2023
1	InflammasomesIBA 01/2023
1	OvalbuminIBA 01/2023
1	Small Cytoplasmic RNAIBA 01/2023
1	ProdrugsIBA 12/2022
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2022
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 12/2022
1	Tadalafil (Cialis)FDA Link 01/2022
1	Guanosine Monophosphate (5' Guanylic Acid)IBA 01/2022
1	Vardenafil Dihydrochloride (Levitra)FDA Link 01/2022
1	Sildenafil Citrate (Viagra)FDA Link 01/2022
1	diethylstilbestrol monophosphate (PDES)IBA 01/2022
1	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 01/2022
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 11/2021
1	T-Lymphocyte Epitopes (Epitopes, T Lymphocyte)IBA 05/2021
1	B-Lymphocyte Epitopes (B-Cell Epitope)IBA 05/2021
1	Protein Subunit VaccinesIBA 05/2021
1	Antitussive Agents (Antitussives)FDA Link 01/2021
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2021
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2021
1	GlobinsIBA 10/2020
1	Small Molecule LibrariesIBA 10/2020
1	Fetal Hemoglobin (Hemoglobin F)IBA 10/2020
1	Cyclic PeptidesIBA 09/2019
1	Explosive Agents (Explosives)IBA 01/2019
1	ZP120IBA 01/2019
1	Proline (L-Proline)FDA Link 01/2018
1	Nootropic Agents (Nootropics)IBA 03/2017
1	CannabinoidsIBA 11/2016
1	hemopressinIBA 11/2016

Therapy/Procedure

3	Therapeutics 08/2011 - 12/2004
1	Intravesical Administration 01/2019